Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 219
interventional 147
Observational 61
Registry 11

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Other 36
Drug 25
Drug|placebo 25
Device 10
Behavioral 9
Biological 8
Dietary Supplement|placebo 5
Procedure 5
Dietary Supplement 3
Dietary Supplement|Other 3
Drug|Procedure 3
Device|Dietary Supplement|placebo 2
Device|Other 2
Drug|Other 2
Other|Procedure 2
Behavioral|Dietary Supplement 1
Behavioral|Dietary Supplement|Drug 1
Behavioral|Dietary Supplement|placebo 1
Behavioral|Other 1
Biological|placebo 1
Device|Dietary Supplement 1
Dietary Supplement|Other|placebo 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 49
United Kingdom 16
France 9
Germany 9
Canada 7
Denmark 5
NA 5
Netherlands 5
United States|Canada 4
Brazil 3
Slovenia 3
Belgium|France|Germany|Italy|Netherlands|Poland|United Kingdom 2
Italy 2
Taiwan 2
Austria 1
Belgium|Bulgaria|Denmark|Germany|Italy|Poland|Russian Federation 1
Belgium|France|Germany 1
Belgium|France|Italy|United Kingdom 1
Greece 1
Japan|Korea, Republic of|Taiwan 1
Norway 1
Singapore 1
Sweden 1
Switzerland 1
Thailand 1
United States|Argentina|Australia|Austria|Belgium|Chile|Colombia|Czechia|France|Germany|Hungary|Japan|Mexico|Russian Federation|Spain|Switzerland|Taiwan|Turkey|United Kingdom 1
United States|Australia|Belgium|Brazil|China|Italy|Poland|Russian Federation|Saudi Arabia|Taiwan 1
United States|Australia|Belgium|Canada|France|Germany|Hong Kong|Italy|Japan|Korea, Republic of|Spain|Sweden|Turkey|United Kingdom 1
United States|Australia|Belgium|Canada|France|Italy|Japan|Korea, Republic of|Spain|Taiwan|United Kingdom 1
United States|Australia|Belgium|Canada|Germany|Israel|Italy|Japan|Korea, Republic of|Spain|Taiwan|United Kingdom 1
United States|Australia|Canada|Germany|Italy|Qatar|Taiwan|Turkey 1
United States|Austria|Belgium|Canada|Denmark|Estonia|Finland|France|Japan|Spain|Sweden 1
United States|Belgium|Brazil|Canada|China|Croatia|France|Germany|Italy|Japan|Poland|Russian Federation|Serbia|Spain|Turkey 1
United States|Belgium|Brazil|China|Croatia|France|Italy|Japan|Poland|Russian Federation|Saudi Arabia|Serbia|Spain|Switzerland|Turkey 1
United States|Belgium|France|Germany|Italy|Netherlands|Poland|Switzerland|United Kingdom 1
United States|Canada|France|Germany|Hong Kong|Italy|Japan|Korea, Republic of|Spain|Sweden 1
United States|Canada|Germany 1
United States|Denmark|Germany|Italy 1
United States|Estonia|Latvia|Spain|Taiwan 1
United States|Italy|Netherlands|Spain 1

Sites per Study

Site_count Study_Count
1 108
2 4
3 2
4 6
6 4
8 1
9 1
10 1
14 1
15 1
16 2
19 2
22 1
24 3
27 1
29 1
30 2
35 1
42 1
43 1
45 1
52 1
56 1

Phase

Phase Study_Count
N/A 76
Phase 2 29
Phase 1 12
Phase 3 9
Phase 1/Phase 2 8
Phase 2/Phase 3 7
Phase 4 4
Early Phase 1 2

Number of Arms

Number_of_Arms Count_of_Studies
1 37
2 73
3 12
4 14
5 2
6 2
NA 7

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 10.0 4.00000 15.00 14.00 12 11.00 6.0000 10.00
1st Qu. 22.5 13.50000 22.50 28.50 25 26.75 30.0000 68.50
Median 35.0 30.00000 27.50 34.00 56 93.50 34.0000 145.50
Mean 35.0 48.93333 35.00 34.75 78 97.50 132.6667 152.25
3rd Qu. 47.5 52.00000 43.25 39.25 82 137.00 292.0000 229.25
Max. 60.0 420.00000 75.00 61.00 400 231.00 330.0000 308.00

Trial Group Type

group_type Group_Count
Experimental 179
Placebo Comparator 47
Active Comparator 33
No Intervention 19
Other 11
Sham Comparator 8
NA 7

Intervention Model

intervention_model Study_Count
Parallel Assignment 76
Single Group Assignment 49
Crossover Assignment 14
Sequential Assignment 4
Factorial Assignment 2
NA 2

Primary Purpose

primary_purpose Study_Count
Treatment 89
Basic Science 26
Prevention 12
Diagnostic 6
Other 6
Supportive Care 4
NA 4

Observational Studies

Studies by Country

Country Study_Count
United States 23
NA 8
United Kingdom 4
France 3
Switzerland 3
Taiwan 3
Belgium 2
Turkey 2
United States|Canada 2
Australia 1
Austria|Switzerland 1
Brazil 1
Canada 1
China 1
Egypt|India|Lebanon|Lithuania|Romania|Sri Lanka|United Arab Emirates 1
Japan 1
Korea, Republic of 1
Mali 1
Netherlands 1
United States|Germany|South Africa 1

Sites per Study

Site_count Study_Count
1 49
2 2
3 4
8 1
11 1
14 1
15 2
18 1

Enrollment Metrics

Measure Observational
Min 12.00
1st Qu 36.00
Median 111.00
Mean 16213.02
3rd Qu 410.00
Max 400000.00

Observation Model

observational_model Study_Count
Cohort 35
Case-Only 7
Other 7
Case-Control 4
Case Control 3
NA 3
Ecologic or Community 1
Natural History 1

Time Perspective

time_perspective Study_Count
Prospective 45
Retrospective 8
Cross-Sectional 6
Longitudinal, Prospective 1
NA 1

Registries

Studies by Country

Country Study_Count
United States 6
France 2
Brazil 1
Egypt 1
United States|Australia 1

Sites per Study

Site_count Study_Count
1 6
2 1
6 1
8 1
9 1
26 1

Enrollment Metrics

Measure Registries
Min 30.000
1st Qu 100.000
Median 200.000
Mean 2382.636
3rd Qu 1024.500
Max 20000.000

Registry Model

observational_model Study_Count
Case-Control 3
Case-Only 3
Cohort 3
Ecologic or Community 1
Family-Based 1

Time Perspective

time_perspective Study_Count
Prospective 6
Other 3
Cross-Sectional 2

Follow-up

target_duration Study_Count
1 Day 2
5 Years 2
1 Year 1
10 Years 1
100 Years 1
15 Years 1
50 Years 1
6 Months 1
9 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04042025 Long-term Follow-up Study of Patients Receiving Onasemnogene Abeparvovec-xioi https://ClinicalTrials.gov/show/NCT04042025 Enrolling by invitation AveXis, Inc. 2034-12-31
NCT03395795 Trial Evaluating the Interest of Noninvasive Ventilation in NAVA Mode in Respiratory Decompensations Children With Infantile Spinal Muscular Atrophy Type II https://ClinicalTrials.gov/show/NCT03395795 Recruiting Assistance Publique - Hôpitaux de Paris 2020-02-29
NCT03819660 Long Term Safety of Amifampridine Phosphate in Spinal Muscular Atrophy 3 https://ClinicalTrials.gov/show/NCT03819660 Enrolling by invitation Catalyst Pharmaceuticals, Inc. 2020-12-31
NCT03332238 Stromal Vascular Fraction Cell Therapy to Improve the Repair of Rotator Cuff Tears https://ClinicalTrials.gov/show/NCT03332238 Recruiting Hospital for Special Surgery, New York 2022-07-31
NCT03306277 Gene Replacement Therapy Clinical Trial for Patients With Spinal Muscular Atrophy Type 1 https://ClinicalTrials.gov/show/NCT03306277 Completed AveXis, Inc. 2019-11-12
NCT03299972 Multidisciplinary Research Into the Effects of Resistance Exercise and Whey Protein Supplementation in Healthy Older Men https://ClinicalTrials.gov/show/NCT03299972 Completed Coventry University 2019-06-30
NCT03267745 Effects of Amino Acid Formulation on Healthy Men Undergoing Unilateral Knee Immobilization https://ClinicalTrials.gov/show/NCT03267745 Completed McMaster University 2017-12-19
NCT03223051 Development of a Space Exploration Assessment for Children With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT03223051 Completed Centre d’Investigation Clinique et Technologique 805 2019-11-22
NCT03204240 Metabolic Health in Individuals With Spinal Cord Injury (SCI) https://ClinicalTrials.gov/show/NCT03204240 Recruiting University of Alabama at Birmingham 2021-08-31
NCT03201094 Impact of NMES and HPRO on Recovery After SAH https://ClinicalTrials.gov/show/NCT03201094 Recruiting University of Maryland, Baltimore 2020-01-31
NCT03195348 The Effects of Whole Body Unloading on Physiological Function https://ClinicalTrials.gov/show/NCT03195348 Completed King’s College London 2017-08-30
NCT03153826 Determinants of Lower Limb Muscle Atrophy Induced During an Hospitalization for Exacerbation of COPD https://ClinicalTrials.gov/show/NCT03153826 Active, not recruiting University Hospital, Montpellier 2019-01-15
NCT03107884 Role of Metformin on Muscle Health of Older Adults https://ClinicalTrials.gov/show/NCT03107884 Recruiting University of Utah 2021-07-01
NCT03059836 n3 PUFA and Muscle-disuse Atrophy in Young Women https://ClinicalTrials.gov/show/NCT03059836 Completed McMaster University 2018-02-28
NCT03054168 Systemic Hormones and Muscle Protein Synthesis https://ClinicalTrials.gov/show/NCT03054168 Active, not recruiting University of Nottingham 2018-11-15
NCT03051984 Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty https://ClinicalTrials.gov/show/NCT03051984 Recruiting University of Vermont 2021-06-30
NCT03046095 The Regulation of Human Skeletal Muscle Mass by Contractile Perturbation https://ClinicalTrials.gov/show/NCT03046095 Completed McMaster University 2018-05-01
NCT03035266 The Effect of Blood Flow Restriction Training on Muscle Atrophy Following Knee Surgery https://ClinicalTrials.gov/show/NCT03035266 Recruiting Keller Army Community Hospital 2020-08-12
NCT03032172 A Study of Risdiplam (RO7034067) in Adult and Pediatric Participants With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT03032172 Active, not recruiting Hoffmann-La Roche 2021-12-31
NCT02949076 Skeletal Muscle Atrophy and Dysfunction in Human Cancer https://ClinicalTrials.gov/show/NCT02949076 Recruiting University of Vermont 2021-06-30
NCT02941328 SPACE Trial: Pyridostigmine vs Placebo in SMA Types 2, 3 and 4 https://ClinicalTrials.gov/show/NCT02941328 Completed UMC Utrecht 2018-01-31
NCT02913482 Investigate Safety, Tolerability, PK, PD and Efficacy of Risdiplam (RO7034067) in Infants With Type1 Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT02913482 Active, not recruiting Hoffmann-La Roche 2019-11-14
NCT02876094 Effect of Low-Dose Celecoxib on SMN2 in Patients With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT02876094 Recruiting Children’s Hospital of Eastern Ontario 2020-07-31
NCT02694471 Effect of 14 Day Bed Rest on Health Outcomes in Young and Older Participants https://ClinicalTrials.gov/show/NCT02694471 Completed University of Primorska 2014-01-31
NCT02644668 A Study of CK-2127107 in Patients With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT02644668 Completed Cytokinetics 2018-05-31
NCT02633709 A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) Given by Mouth in Healthy Volunteers https://ClinicalTrials.gov/show/NCT02633709 Completed Hoffmann-La Roche 2016-08-04
NCT02628743 A Study to Evaluate Long Term Safety, Tolerability, and Effectiveness of Olesoxime in Patients With Spinal Muscular Atrophy (SMA) https://ClinicalTrials.gov/show/NCT02628743 Completed Hoffmann-La Roche 2018-12-18
NCT02594124 A Study for Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in Nusinersen (ISIS 396443) Investigational Studies. https://ClinicalTrials.gov/show/NCT02594124 Active, not recruiting Biogen 2023-08-29
NCT04089566 Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT04089566 Recruiting Biogen 2022-09-26
NCT03401944 Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics. https://ClinicalTrials.gov/show/NCT03401944 Completed Göteborg University 2014-12-31
NCT02566590 Preventing the Loss of Muscle and Function in Hospitalized Older Adults https://ClinicalTrials.gov/show/NCT02566590 Completed University of Utah 2016-12-31
NCT02495727 Two Weeks of Reduced Activity and Skeletal Muscle Health in Older Men https://ClinicalTrials.gov/show/NCT02495727 Completed University of Bath 2017-10-31
NCT02467153 Vitamin D and Resistance Exercise Training; Effects on Musculoskeletal Health in Frail Older Men and Women https://ClinicalTrials.gov/show/NCT02467153 Recruiting University of Birmingham 2019-07-31
NCT02442479 Maximizing Mechanisms of Muscle Hypertrophy to Combat Sarcopenia in Older Adults https://ClinicalTrials.gov/show/NCT02442479 Completed University of Alabama at Birmingham 2012-03-31
NCT02428673 Effects of Standing on Non-Ambulatory Children With Neuromuscular Conditions https://ClinicalTrials.gov/show/NCT02428673 Active, not recruiting Gillette Children’s Specialty Healthcare 2019-03-31
NCT02420353 Evaluation of rGH Therapy to Prevent Muscle Atrophy in Patients With ACL Tears https://ClinicalTrials.gov/show/NCT02420353 Completed University of Michigan 2018-10-31
NCT02391103 Effects of Neuromuscular Electrical Stimulation on Muscle Mass and Strength in Critically Ill Patients After Cardiothoracic Surgery https://ClinicalTrials.gov/show/NCT02391103 Completed Medical University of Vienna 2012-07-31
NCT02386553 A Study of Multiple Doses of Nusinersen (ISIS 396443) Delivered to Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT02386553 Active, not recruiting Biogen 2025-02-25
NCT02376309 The Effect of Nandrolone Decanoate and Leucine on Muscle Loss https://ClinicalTrials.gov/show/NCT02376309 Completed Maastricht University Medical Center 2016-08-31
NCT02341053 Effects of Standing on Non-Ambulatory Children With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT02341053 Active, not recruiting Gillette Children’s Specialty Healthcare 2019-12-31
NCT02292537 A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA) https://ClinicalTrials.gov/show/NCT02292537 Completed Biogen 2017-02-20
NCT02268552 An Open Label Study of LMI070 (Branaplam) in Type 1 Spinal Muscular Atrophy (SMA) https://ClinicalTrials.gov/show/NCT02268552 Active, not recruiting Novartis 2020-07-23
NCT02156141 High Intensity Training in Patients With Spinal and Bulbar Muscular Atrophy https://ClinicalTrials.gov/show/NCT02156141 Completed Rigshospitalet, Denmark 2016-06-30
NCT02152761 Study of Efficacy and Safety of Bimagrumab in Patients After Hip Fracture Surgery https://ClinicalTrials.gov/show/NCT02152761 Completed Novartis 2018-05-14
NCT02145949 Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults https://ClinicalTrials.gov/show/NCT02145949 Recruiting University of Oregon 2019-10-31
NCT02122952 Gene Transfer Clinical Trial for Spinal Muscular Atrophy Type 1 https://ClinicalTrials.gov/show/NCT02122952 Completed AveXis, Inc. 2017-12-15
NCT02061189 Pilot Study of an Innovative Physiotherapy in Patients With Infantile Spinal Muscular Atrophy (SMA) https://ClinicalTrials.gov/show/NCT02061189 Active, not recruiting Assistance Publique - Hôpitaux de Paris 2020-04-30
NCT01302600 Safety and Efficacy of Olesoxime (TRO19622) in 3-25 Years SMA Patients. https://ClinicalTrials.gov/show/NCT01302600 Completed Hoffmann-La Roche 2013-10-31
NCT02057094 Effects of Protein Supplementation on Lean Body Mass Recovery From Extreme Military Training https://ClinicalTrials.gov/show/NCT02057094 Completed United States Army Research Institute of Environmental Medicine 2015-03-31
NCT02052791 An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in ISIS 396443-CS2 (NCT01703988) or ISIS 396443-CS10 (NCT01780246) https://ClinicalTrials.gov/show/NCT02052791 Completed Biogen 2017-01-31
NCT02034942 Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation - Effects on Physical Function https://ClinicalTrials.gov/show/NCT02034942 Completed Odense University Hospital 2017-06-30
NCT02003937 Aerobic Training in Patients With Spinal Muscular Atrophy Type III https://ClinicalTrials.gov/show/NCT02003937 Completed Rigshospitalet, Denmark 2010-09-30
NCT01991171 Effectiveness of the Kinesio Taping® in Muscle Activation https://ClinicalTrials.gov/show/NCT01991171 Completed Paulista University 2013-06-30
NCT01981915 Optimum Insufflation Capacity in NMD https://ClinicalTrials.gov/show/NCT01981915 Completed Universität Duisburg-Essen 2013-02-28
NCT01900873 Effects of Inspiratory Muscle Training on Dyspnea Perception During Exercise in Patients With COPD https://ClinicalTrials.gov/show/NCT01900873 Completed KU Leuven 2014-09-30
NCT01862042 Palliative Care in Spinal Muscular Atrophy (SMA) 1 https://ClinicalTrials.gov/show/NCT01862042 Completed Assistance Publique - Hôpitaux de Paris 2018-06-11
NCT01839656 A Study to Assess the Efficacy, Safety and Pharmacokinetics of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy (SMA) https://ClinicalTrials.gov/show/NCT01839656 Completed Biogen 2017-08-21
NCT01820702 Short Term Bed Rest Study: Evaluation of the Use of Artificial Gravity, Induced by Short-arm Centrifugation https://ClinicalTrials.gov/show/NCT01820702 Completed DLR German Aerospace Center 2011-05-31
NCT01791010 Effects of Inspiratory Muscle Training in Elders https://ClinicalTrials.gov/show/NCT01791010 Completed Universidade Federal de Pernambuco 2012-12-31
NCT01788111 Occurrence, Diagnosis and Treatment of Neck and Back Pain in Helicopter Pilots. https://ClinicalTrials.gov/show/NCT01788111 Completed Helse Stavanger HF 2019-12-31
NCT01780246 An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy Who Previously Participated in ISIS 396443-CS1 (NCT01494701) https://ClinicalTrials.gov/show/NCT01780246 Completed Biogen 2014-02-28
NCT01703988 An Open-label Safety, Tolerability and Dose-Range Finding Study of Multiple Doses of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT01703988 Completed Biogen 2015-01-31
NCT02024932 Safety, Tolerability, and Efficacy of BVS857 in Patients With Spinal and Bulbar Muscular Atrophy https://ClinicalTrials.gov/show/NCT02024932 Completed Novartis 2016-04-13
NCT01645787 Short and Long Term Treatment With 4-AP in Ambulatory SMA Patients https://ClinicalTrials.gov/show/NCT01645787 Completed Columbia University 2015-09-30
NCT01641627 Preventive Effect of Proprioceptive Stimulation on Muscle Atrophy https://ClinicalTrials.gov/show/NCT01641627 Completed University Hospital, Lille 2014-12-31
NCT01624792 Eicosapentaenoic Acid and Protein Modulation to Induce Anabolism in Chronic Obstructive Pulmonary Disease (COPD): Aim 2 https://ClinicalTrials.gov/show/NCT01624792 Active, not recruiting Texas A&M University 2016-06-30
NCT01611610 Clinical Assessment of Spinal Muscular Atrophy Type II and III (SMA Europe) https://ClinicalTrials.gov/show/NCT01611610 Completed Institut de Myologie, France 2013-05-31
NCT01522079 Spinal Muscular Atrophy and Cardiac Autonomic Function https://ClinicalTrials.gov/show/NCT01522079 Completed Centro Universitário Augusto Motta 2011-08-31
NCT01509456 The Effect of Potassium Bicarbonate on Bone and Several Physiological Systems During Immobilisation https://ClinicalTrials.gov/show/NCT01509456 Completed DLR German Aerospace Center 2010-10-31
NCT01494701 An Open-label Safety, Tolerability, and Dose-range Finding Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA) https://ClinicalTrials.gov/show/NCT01494701 Completed Biogen 2013-01-31
NCT01476072 31P MRS Ischaemic Exercise Optimisation and COPD https://ClinicalTrials.gov/show/NCT01476072 Completed GlaxoSmithKline 2011-08-31
NCT01372176 Early Goal-Directed Nutrition in ICU Patients - EAT-ICU Trial https://ClinicalTrials.gov/show/NCT01372176 Completed Rigshospitalet, Denmark 2016-11-30
NCT01369511 A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement https://ClinicalTrials.gov/show/NCT01369511 Completed Eli Lilly and Company 2014-02-28
NCT01355497 Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) on First Line Platinum https://ClinicalTrials.gov/show/NCT01355497 Completed GTx 2013-05-31
NCT01344135 Nutritional Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Muscle Atrophy https://ClinicalTrials.gov/show/NCT01344135 Completed Maastricht University Medical Center 2015-06-30
NCT01321320 Investigation of the Role of FHL-1 and Myostatin in Intensive Care Unit Acquired Paresis (ICUAP) https://ClinicalTrials.gov/show/NCT01321320 Completed Imperial College London 2013-10-31
NCT04420806 Effects of COVID-19 Lockdown in Exercising Early Postmenopausal Women https://ClinicalTrials.gov/show/NCT04420806 Active, not recruiting University of Erlangen-Nürnberg Medical School 2020-06-30
NCT04357184 BFRT for Severe Lower Extremity Muscle Atrophy https://ClinicalTrials.gov/show/NCT04357184 Recruiting Cincinnati Sportsmedicine Research and Education Foundation 2022-04-30
NCT04266015 Anabolic Effects of Intraoperative Feeding in Reconstruction Surgery https://ClinicalTrials.gov/show/NCT04266015 Recruiting E-DA Hospital 2022-03-30
NCT04262570 Evaluation of Therapeutic Response in Spinal Muscular Atrophy Using Multispectral Optoacoustic Tomography (MSOT) and Magnetic Resonance Imaging (MRI) https://ClinicalTrials.gov/show/NCT04262570 Recruiting University of Erlangen-Nürnberg Medical School 2021-12-31
NCT04199923 Mechanisms of Disuse Atrophy in Human Skeletal Muscle (iMOB) https://ClinicalTrials.gov/show/NCT04199923 Recruiting University of Nottingham 2021-05-01
NCT04147741 Effects of a Pre-Workout on Performance, Perceptual Responses, Energy Feelings and Muscular Properties, After a Training Microcycle in Adults. https://ClinicalTrials.gov/show/NCT04147741 Recruiting University of Greenwich 2019-12-06
NCT04115475 New Imaging Biomarkers for Muscular Diseases - Multispectral Optoacoustic Imaging in Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT04115475 Active, not recruiting University of Erlangen-Nürnberg Medical School 2020-01-30
NCT04081467 Biological and Functional Markers for Precision Astronautical Biomedicine https://ClinicalTrials.gov/show/NCT04081467 Completed Science and Research Centre Koper 2019-10-16
NCT04067167 Flexi Band Resistance Training Versus EMS Exercise in Patients With the Diagnosis of Malignant Diseases https://ClinicalTrials.gov/show/NCT04067167 Recruiting University of Erlangen-Nürnberg Medical School 2022-03-31
NCT04057833 E-CEL UVEC Cells as an Adjunct Cell Therapy for the Arthroscopic Rotator Cuff Repair in Adults https://ClinicalTrials.gov/show/NCT04057833 Recruiting Hospital for Special Surgery, New York 2020-11-26
NCT04050852 Pulmonary Function Test Changes and Respiratory Muscle Strength Trends in Spinal Muscular Atrophy Patients Receiving Nusinersen Treatments https://ClinicalTrials.gov/show/NCT04050852 Recruiting NYU Langone Health 2020-07-17
NCT03988907 A Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants https://ClinicalTrials.gov/show/NCT03988907 Completed Hoffmann-La Roche 2019-09-29
NCT03970135 Fat and Glucose Metabolism in Fed and Fasted State in Patients With Low Skeletal Muscle Mass https://ClinicalTrials.gov/show/NCT03970135 Completed Rigshospitalet, Denmark 2017-11-30
NCT03921528 An Active Treatment Study of SRK-015 in Patients With Type 2 or Type 3 Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT03921528 Active, not recruiting Scholar Rock, Inc. 2021-01-31
NCT03920865 A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of a Single Oral Dose of Risdiplam Compared to Matched Healthy Participants With Normal Hepatic Function https://ClinicalTrials.gov/show/NCT03920865 Completed Hoffmann-La Roche 2020-01-02
NCT03837184 Single-Dose Gene Replacement Therapy Using for Patients With Spinal Muscular Atrophy Type 1 With One or Two SMN2 Copies https://ClinicalTrials.gov/show/NCT03837184 Recruiting AveXis, Inc. 2021-04-01
NCT03808519 n3 PUFA and Muscle-disuse Atrophy in Older Women https://ClinicalTrials.gov/show/NCT03808519 Active, not recruiting McMaster University 2020-02-01
NCT03797781 Protein Ingestion and Skeletal Muscle Atrophy https://ClinicalTrials.gov/show/NCT03797781 Recruiting University of Exeter 2019-03-31
NCT03781479 Controlled Trial to Evaluate Amifampridine Phosphate in Spinal Muscular Atrophy Type 3 Patients https://ClinicalTrials.gov/show/NCT03781479 Recruiting Catalyst Pharmaceuticals, Inc. 2020-05-15
NCT03779334 A Study of Risdiplam in Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT03779334 Recruiting Hoffmann-La Roche 2021-06-21
NCT03762278 Can Supplemental Leucine Offset Disuse-induced Muscle Atrophy? https://ClinicalTrials.gov/show/NCT03762278 Completed University of Birmingham 2019-02-01
NCT03761446 The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults https://ClinicalTrials.gov/show/NCT03761446 Recruiting Translational Research Institute for Metabolism and Diabetes, Florida 2023-05-31
NCT03690258 Effects of Variable Load Exercise on Aging Atrophy https://ClinicalTrials.gov/show/NCT03690258 Recruiting University Hospital of Split 2020-03-30
NCT03587870 Protein Delivery in Intermittent and Continuous Enteral Nutrition in ICU Patients https://ClinicalTrials.gov/show/NCT03587870 Recruiting University Hospital, Basel, Switzerland 2020-12-31
NCT04456530 Use of Testosterone to Prevent Post-Surgical Muscle Loss - Pilot Study https://ClinicalTrials.gov/show/NCT04456530 Enrolling by invitation The Stone Research Foundation for Sports Medicine and Arthritis 2020-12-30
NCT03560713 Effects of Functional Electrical Stimulation in Patients Undergoing Coronary Artery Bypass Grafting Surgery https://ClinicalTrials.gov/show/NCT03560713 Completed Universidade Federal de Santa Maria 2019-12-20
NCT03551990 Influence of Motor Proteins on Muscle Atrophy in Cancer Patients https://ClinicalTrials.gov/show/NCT03551990 Recruiting University of Erlangen-Nürnberg Medical School 2021-12-31
NCT03540732 Feeding With Indirect Calorimetry and Cycling in the Elderly https://ClinicalTrials.gov/show/NCT03540732 Recruiting National University Hospital, Singapore 2020-12-31
NCT03505099 Pre-Symptomatic Study of Intravenous Onasemnogene Abeparvovec-xioi in Spinal Muscular Atrophy (SMA) for Patients With Multiple Copies of SMN2 https://ClinicalTrials.gov/show/NCT03505099 Active, not recruiting AveXis, Inc. 2021-06-24
NCT03495128 Metabolic and Muscular Adaptations During Inactivity in 3 Days of Bed-rest https://ClinicalTrials.gov/show/NCT03495128 Completed University of Nottingham 2018-07-31
NCT03464708 A Study to Investigate the Effect of HMB on Skeletal Muscle Wasting in Early Critical Illness https://ClinicalTrials.gov/show/NCT03464708 Recruiting Guy’s and St Thomas’ NHS Foundation Trust 2020-05-31
NCT03461289 Single-Dose Gene Replacement Therapy Clinical Trial for Patients With Spinal Muscular Atrophy Type 1 https://ClinicalTrials.gov/show/NCT03461289 Active, not recruiting AveXis, Inc. 2020-09-30
NCT03441347 Neuralgic Amyotrophy: Central Reorganization and Rehabilitation After Peripheral Dysfunction https://ClinicalTrials.gov/show/NCT03441347 Enrolling by invitation Radboud University 2020-12-31
NCT03440593 Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients https://ClinicalTrials.gov/show/NCT03440593 Enrolling by invitation Baylor Research Institute 2020-12-31
NCT01233817 Progressive Strength Training in Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT01233817 Completed University of Utah 2013-06-30
NCT01166022 Clinical Trial of Exercise in Patients With Spinal Muscular Atrophy (SMA) https://ClinicalTrials.gov/show/NCT01166022 Completed Columbia University 2014-08-31
NCT01080196 Reducing Falls With RENEW in Older Adults Who Have Fallen https://ClinicalTrials.gov/show/NCT01080196 Completed University of Utah 2014-02-28
NCT01028833 Effects of Power Mobility on Young Children With Severe Motor Impairments https://ClinicalTrials.gov/show/NCT01028833 Completed University of Oklahoma 2012-12-31
NCT00964340 A Clinical Study to Assess the Safety, Tolerability and Pharmacokinetics of Oral SRT2104 Capsules Administered to Healthy Elderly Subjects for 28 Days https://ClinicalTrials.gov/show/NCT00964340 Completed GlaxoSmithKline 2010-04-27
NCT00952887 A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 in Healthy Postmenopausal Women https://ClinicalTrials.gov/show/NCT00952887 Completed Acceleron Pharma, Inc. 2011-02-28
NCT00924625 The Use of Neuromuscular Electrical Stimulation to Reverse Muscle Atrophy in Patients With Rheumatoid Arthritis https://ClinicalTrials.gov/show/NCT00924625 Completed University of Pittsburgh 2013-12-31
NCT00922857 Influence of Muscular Atrophy on Biological and Functional Benefit of Respiratory Rehabilitation in Patients With Chronic Respiratory Failure https://ClinicalTrials.gov/show/NCT00922857 Completed Centre Hospitalier Universitaire de Saint Etienne 2013-09-30
NCT00851461 Effect of Goserelin (Zoladex®) in Spinal and Bulbar Muscular Atrophy https://ClinicalTrials.gov/show/NCT00851461 Completed Ramathibodi Hospital 2011-11-30
NCT02562495 Ultrasound to Evaluate the Quadriceps Muscle Wasting https://ClinicalTrials.gov/show/NCT02562495 Completed Centre Hospitalier Universitaire de Saint Etienne 2017-08-31
NCT02391831 Prospective Study of the Natural History of Patients With Type 2 and 3 Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT02391831 Completed Institut de Myologie, France 2018-06-30
NCT01369901 Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy https://ClinicalTrials.gov/show/NCT01369901 Completed National Institutes of Health Clinical Center (CC) NA
NCT01355484 Phase III Study of the Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) https://ClinicalTrials.gov/show/NCT01355484 Completed GTx 2013-05-31
NCT02984332 Timecourse of Immobilization Experiment https://ClinicalTrials.gov/show/NCT02984332 Completed University of Exeter 2017-12-31
NCT02912130 Exercise and Nutrition Interventions in Age-related Sarcopenia https://ClinicalTrials.gov/show/NCT02912130 Recruiting Liverpool Hope University 2019-02-28
NCT02908685 A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of Risdiplam (RO7034067) in Type 2 and 3 Spinal Muscular Atrophy (SMA) Participants https://ClinicalTrials.gov/show/NCT02908685 Active, not recruiting Hoffmann-La Roche 2019-09-06
NCT04450615 Core Exercises Effects on Muscle Imbalances https://ClinicalTrials.gov/show/NCT04450615 Active, not recruiting Aristotle University Of Thessaloniki 2020-07-30
NCT00787098 Investigating Modes of Progressive Mobility https://ClinicalTrials.gov/show/NCT00787098 Completed Hill-Rom 2009-04-30
NCT00774423 Study to Evaluate the Efficacy of Riluzole in Children and Young Adults With Spinal Muscular Atrophy (SMA) https://ClinicalTrials.gov/show/NCT00774423 Completed Assistance Publique - Hôpitaux de Paris 2011-09-30
NCT00661453 CARNIVAL Type I: Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy (SMA) Type I https://ClinicalTrials.gov/show/NCT00661453 Completed University of Utah 2012-05-31
NCT00635440 Randomized, Controlled Study to Investigate the Effect of Neuromuscular Electrical Stimulation (NMES) on Muscle Metabolism of Abdominal Surgical Patients https://ClinicalTrials.gov/show/NCT00635440 Completed Medical University of Vienna NA
NCT00568802 A Pilot Therapeutic Trial Using Hydroxyurea in Type II and Type III Spinal Muscular Atrophy Patients https://ClinicalTrials.gov/show/NCT00568802 Completed Stanford University 2010-03-31
NCT00568698 A Pilot Therapeutic Trial Using Hydroxyurea in Type I Spinal Muscular Atrophy Patients https://ClinicalTrials.gov/show/NCT00568698 Completed Stanford University 2012-02-29
NCT00533221 Pilot Study of Growth Hormon to Treat SMA Typ II and III https://ClinicalTrials.gov/show/NCT00533221 Completed University Hospital Freiburg 2010-02-28
NCT00528268 Study to Evaluate Sodium Phenylbutyrate in Pre-symptomatic Infants With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT00528268 Completed University of Utah 2013-12-31
NCT00485511 A Trial of Hydroxyurea in Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT00485511 Completed Kaohsiung Medical University Chung-Ho Memorial Hospital 2009-06-30
NCT00481013 Valproic Acid in Ambulant Adults With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT00481013 Completed University of Utah 2009-12-31
NCT00475501 5-Alpha Reductase and Anabolic Effects of Testosterone https://ClinicalTrials.gov/show/NCT00475501 Completed VA Office of Research and Development 2012-03-31
NCT00467844 Study of GTx-024 on Muscle Wasting (Cachexia) Cancer. https://ClinicalTrials.gov/show/NCT00467844 Completed GTx 2008-09-30
NCT00447044 Combined Effects of Nutritional and Exercise Countermeasures https://ClinicalTrials.gov/show/NCT00447044 Completed University of Arkansas 2009-06-30
NCT00374075 Study of Safety and Dosing Effect on SMN Levels of Valproic Acid (VPA) in Patients With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT00374075 Completed University of Utah NA
NCT00324454 Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease https://ClinicalTrials.gov/show/NCT00324454 Completed Duke University 2007-12-31
NCT00303446 Dutasteride to Treat Spinal and Bulbar Muscular Atrophy (SBMA) https://ClinicalTrials.gov/show/NCT00303446 Completed National Institutes of Health Clinical Center (CC) 2009-12-31
NCT00227266 Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT00227266 Completed University of Utah 2007-11-30
NCT00018356 Physiologic Effects of PRMS & Testosterone in the Debilitated Elderly https://ClinicalTrials.gov/show/NCT00018356 Completed VA Office of Research and Development 2006-07-31
NCT00004771 Phase II Study of Leuprolide and Testosterone for Men With Kennedy’s Disease or Other Motor Neuron Disease https://ClinicalTrials.gov/show/NCT00004771 Completed Office of Rare Diseases (ORD) NA
NCT00006194 Effects of Exercise on Markers of Inflammation in Skeletal Muscle in Elderly Hip Fracture Patients https://ClinicalTrials.gov/show/NCT00006194 Completed National Center for Research Resources (NCRR) NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03300869 Natural History of Types 2 and 3 SMA in Taiwan https://ClinicalTrials.gov/show/NCT03300869 Recruiting Kaohsiung Medical University Chung-Ho Memorial Hospital 2019-12-31
NCT03269825 The Use of Computed Tomography (CT) to Measure Skeletal Muscle Quantity and Quality in Patients Receiving ECMO https://ClinicalTrials.gov/show/NCT03269825 Completed Guy’s and St Thomas’ NHS Foundation Trust 2018-05-31
NCT03229395 Alterations of Muscle Secretome Associated With Muscle Atrophy Caused by Glucocorticoids https://ClinicalTrials.gov/show/NCT03229395 Completed Cliniques universitaires Saint-Luc- Université Catholique de Louvain 2017-07-13
NCT03217578 Neonatal Spinal Muscular Atrophy (SMA) Screening https://ClinicalTrials.gov/show/NCT03217578 Recruiting Kaohsiung Medical University Chung-Ho Memorial Hospital 2019-12-31
NCT03026985 Acute Skeletal Muscle Wasting and Relation to Physical Function in Patients Requiring ECMO https://ClinicalTrials.gov/show/NCT03026985 Completed The Alfred 2017-09-19
NCT03012139 Cancer-Associated Muscle Atrophy and Weakness: An Investigation of Etiology https://ClinicalTrials.gov/show/NCT03012139 Completed Mayo Clinic 2019-10-11
NCT02994030 Biomarker for Duchenne Muscular Dystrophy https://ClinicalTrials.gov/show/NCT02994030 Recruiting Centogene AG Rostock 2023-12-31
NCT02895789 Oxidative Capacity and Exercise Tolerance in Ambulatory SMA https://ClinicalTrials.gov/show/NCT02895789 Recruiting Columbia University 2020-04-30
NCT02852278 A Patient Centric Motor Neuron Disease Activities of Daily Living Scale https://ClinicalTrials.gov/show/NCT02852278 Completed University of South Florida 2019-09-13
NCT02839460 A Prospective Study Of Biomarkers Of Skeletal Muscle Atrophy https://ClinicalTrials.gov/show/NCT02839460 Completed University of Florida 2018-03-31
NCT02124057 Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy https://ClinicalTrials.gov/show/NCT02124057 Recruiting National Institutes of Health Clinical Center (CC) 2020-12-31
NCT02555670 Relation Between Bioelectrical Impedance Analysis (BIA) and CT-scan Analysis in the ICU https://ClinicalTrials.gov/show/NCT02555670 Completed VU University Medical Center 2015-05-31
NCT02532244 Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases https://ClinicalTrials.gov/show/NCT02532244 Recruiting Nemours Children’s Clinic 2022-12-31
NCT02466529 Natural History of Spinal Muscular Atrophy Type 1 in Taiwan https://ClinicalTrials.gov/show/NCT02466529 Completed Kaohsiung Medical University Chung-Ho Memorial Hospital 2015-12-31
NCT02327845 Phenotype, Genotype & Biomarkers in ALS and Related Disorders https://ClinicalTrials.gov/show/NCT02327845 Recruiting University of Miami 2021-06-30
NCT02270502 Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit https://ClinicalTrials.gov/show/NCT02270502 Completed Massachusetts General Hospital 2015-12-31
NCT02174029 Serial Daily Diaphragm Ultrasounds in Ventilated Patients https://ClinicalTrials.gov/show/NCT02174029 Completed Fraser Health 2014-08-31
NCT02123186 Newborn Screening for Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT02123186 Completed National Taiwan University Hospital 2016-10-31
NCT02080936 Does Muscle Wasting Always Mean Muscle Weakness? A Prevalence Study in COPD https://ClinicalTrials.gov/show/NCT02080936 Completed 5 Santé 2014-03-31
NCT02044029 Ability of Muscle Imaging and Motor Function Measure (MFM) to Detect Changes in Disease Progression in Ambulant Spinal Muscular Atrophy Patients Compared to Healthy Volunteers. https://ClinicalTrials.gov/show/NCT02044029 Completed Hoffmann-La Roche 2015-07-31
NCT03354767 The Role of Ischaemia-reperfusion Injury in the Pathogenesis of Muscle Wasting After Thoracic Aortic Surgery https://ClinicalTrials.gov/show/NCT03354767 Completed Imperial College London 2014-10-31
NCT04448626 Micro-environment Involvement in Muscle Alteration Induced https://ClinicalTrials.gov/show/NCT04448626 Completed University Hospital, Montpellier 2020-05-01
NCT01931644 At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions https://ClinicalTrials.gov/show/NCT01931644 Recruiting Sanguine Biosciences 2025-08-31
NCT01910168 A Study to Collect Blood Samples From Patients With Spinal Muscular Atrophy for Biomarker Analysis https://ClinicalTrials.gov/show/NCT01910168 Completed Hoffmann-La Roche 2014-02-28
NCT01821183 Strength and Strength-ratio of Hip Rotator Muscles at Soccer Players https://ClinicalTrials.gov/show/NCT01821183 Completed University Hospital, Basel, Switzerland 2013-08-31
NCT01754441 Mechanisms of Cell Death in Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT01754441 Completed Nemours Children’s Clinic 2020-02-29
NCT01736553 Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development https://ClinicalTrials.gov/show/NCT01736553 Completed Ohio State University 2015-09-30
NCT04139343 Motor Unit Number Estimation (MUNE) in Adults With Spinal Muscular Atrophy (SMA) https://ClinicalTrials.gov/show/NCT04139343 Recruiting Ohio State University 2020-12-31
NCT01636375 Comparison of Muscle Atrophy After Direct Anterior & Posterior Total Hip Arthroplasty https://ClinicalTrials.gov/show/NCT01636375 Active, not recruiting Northwell Health 2020-06-30
NCT01459302 Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders https://ClinicalTrials.gov/show/NCT01459302 Recruiting University of Massachusetts, Worcester 2021-10-31
NCT04444739 Association Between Lumbar Muscle Atrophy, Sagittal Pelvic Alignment and Stenosis Grade in Patients With Degenerative Lumbar Spinal Stenosis https://ClinicalTrials.gov/show/NCT04444739 Recruiting University Hospital, Basel, Switzerland 2021-02-28
NCT04333186 Expiratory Muscle Function in Critically Ill Ventilated Patients https://ClinicalTrials.gov/show/NCT04333186 Active, not recruiting VU University Medical Center 2019-11-28
NCT04317794 Observational, Postmarketing Surveillance Study of Spinraza Injection (Nusinersen Sodium) https://ClinicalTrials.gov/show/NCT04317794 Recruiting Biogen 2022-05-11
NCT04292574 UK Spinal Muscular Atrophy Patient Registry https://ClinicalTrials.gov/show/NCT04292574 Recruiting Newcastle University 2021-12-01
NCT04228718 The Burden of Primary Caregivers of Spinal Muscular Atrophy Patients and Their Needs https://ClinicalTrials.gov/show/NCT04228718 Completed Marmara University 2020-02-28
NCT04193085 Wearable Technology to Assess Gait Function in SMA and DMD https://ClinicalTrials.gov/show/NCT04193085 Recruiting Columbia University 2020-12-31
NCT04114383 Concurrent Assessment of Skeletal Muscle Mass and Synthesis/Breakdown in Old Age https://ClinicalTrials.gov/show/NCT04114383 Completed University of Nottingham 2020-01-31
NCT04010604 A Registered Cohort Study on SMA https://ClinicalTrials.gov/show/NCT04010604 Recruiting First Affiliated Hospital of Fujian Medical University 2039-12-31
NCT03912987 TRIAL READY (Clinical Trial Readiness) https://ClinicalTrials.gov/show/NCT03912987 Recruiting University of Miami 2022-01-31
NCT03878030 Effect of Nusinersen on Adults With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT03878030 Active, not recruiting Northwell Health 2023-01-01
NCT03808233 Reliability and Validity of the ACTIVE-mini for Quantifying Movement in Infants With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT03808233 Completed University of Texas Southwestern Medical Center 2018-06-01
NCT03736005 Skeletal Muscle Wasting and Renal Dysfunction After Critical Illness Trauma - Outcomes Study https://ClinicalTrials.gov/show/NCT03736005 Recruiting Queen Mary University of London 2020-05-31
NCT03709784 Spinraza in Adult Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT03709784 Recruiting Washington University School of Medicine 2022-01-30
NCT03660969 Reliability of Cardiac Troponins for the Diagnosis of Myocardial Infarction in the Presence of Skeletal Muscle Disease https://ClinicalTrials.gov/show/NCT03660969 Recruiting University Hospital, Basel, Switzerland 2022-01-01
NCT03655223 Early Check: Expanded Screening in Newborns https://ClinicalTrials.gov/show/NCT03655223 Enrolling by invitation RTI International 2021-06-30
NCT03583177 Muscle Wasting in Hemodialysis Patient https://ClinicalTrials.gov/show/NCT03583177 Completed University Hospital, Clermont-Ferrand 2013-07-31
NCT03555578 Specified Drug-Use Survey of Leuprorelin Acetate Injection Kit 11.25 mg “All-Case Investigation: Spinal and Bulbar Muscular Atrophy (SBMA)” https://ClinicalTrials.gov/show/NCT03555578 Recruiting Takeda 2025-08-31
NCT03554343 Sun May Arise on SMA : Newborn Screening of Spinal Muscular Atrophy in Belgium https://ClinicalTrials.gov/show/NCT03554343 Recruiting Centre Hospitalier Régional de la Citadelle 2021-03-04
NCT03489278 Clinical Procedures to Support Research in ALS https://ClinicalTrials.gov/show/NCT03489278 Recruiting University of Miami 2024-06-30
NCT03421977 Long-Term Follow-up Study for Patients From AVXS-101-CL-101 https://ClinicalTrials.gov/show/NCT03421977 Active, not recruiting AveXis, Inc. 2033-12-31
NCT01059240 SMN Copy Number Distribution in Mali, West Africa https://ClinicalTrials.gov/show/NCT01059240 Completed National Institutes of Health Clinical Center (CC) NA
NCT01033331 Evaluation of the Muscle Strength and Motor Ability in Children With Spinal Muscle Atrophy(SMA) Treated With Valproic Acid https://ClinicalTrials.gov/show/NCT01033331 Completed University of Sao Paulo General Hospital 2008-08-31
NCT04042818 Reliability of Rehabilitative Ultrasound for the Quadriceps Muscle and Sarcopenia in Poststroke Patients https://ClinicalTrials.gov/show/NCT04042818 Recruiting Gaziosmanpasa Taksim Research and Education Hospital 2019-12-30
NCT00835601 Resistive/Cardiovascular Training Study https://ClinicalTrials.gov/show/NCT00835601 Completed University of California, San Francisco 2011-02-28
NCT02817646 Study in ICU Patients Regarding Protein Intake and CT-derived Body Composition https://ClinicalTrials.gov/show/NCT02817646 Completed VU University Medical Center 2016-10-31
NCT01302197 Muscle Atrophy, Physical Performance and Glucose Tolerance Post Stroke https://ClinicalTrials.gov/show/NCT01302197 Active, not recruiting Baltimore VA Medical Center 2020-12-31
NCT00756821 A Pilot Study of Biomarkers for Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT00756821 Completed HealthCore-NERI 2009-03-31
NCT00443066 Clinical Study of Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT00443066 Active, not recruiting Columbia University 2020-10-31
NCT00061607 Measuring Levels of SMN in Blood Samples of SMA Patients https://ClinicalTrials.gov/show/NCT00061607 Completed National Institutes of Health Clinical Center (CC) NA
NCT00060970 Evaluating Muscle Function After Ankle Surgery https://ClinicalTrials.gov/show/NCT00060970 Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) NA
NCT00004769 Study of Muscle Wasting and Altered Metabolism in Patients With Myotonic Dystrophy https://ClinicalTrials.gov/show/NCT00004769 Completed University of Rochester 2000-03-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03339830 European Registry of Patients With Infantile-onset Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT03339830 Recruiting Institut de Myologie, France 2022-12-01
NCT02831296 Prospective Evaluation of Infants With Spinal Muscular Atrophy: https://ClinicalTrials.gov/show/NCT02831296 Recruiting Massachusetts General Hospital 2022-03-31
NCT02574390 Answer ALS: Individualized Initiative for ALS Discovery https://ClinicalTrials.gov/show/NCT02574390 Completed Johns Hopkins University 2019-12-31
NCT02124616 National Registry for Egyptian Pediatric Neuromuscular Diseases https://ClinicalTrials.gov/show/NCT02124616 Recruiting Ain Shams University 2020-04-30
NCT01793168 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford https://ClinicalTrials.gov/show/NCT01793168 Recruiting Sanford Health 2100-12-31
NCT04177134 French Register of Patients With Spinal Muscular Atrophy https://ClinicalTrials.gov/show/NCT04177134 Recruiting Assistance Publique - Hôpitaux de Paris 2029-01-31
NCT04174157 Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA) https://ClinicalTrials.gov/show/NCT04174157 Recruiting AveXis, Inc. 2038-06-30
NCT03706391 Study of ALS Reversals 4: LifeTime Exposures https://ClinicalTrials.gov/show/NCT03706391 Enrolling by invitation Duke University 2020-08-01
NCT03464903 Study of ALS Reversals 2: Genetic Analyses https://ClinicalTrials.gov/show/NCT03464903 Enrolling by invitation Duke University 2020-08-01
NCT04404764 Characterization of the Clinical-epidemiological Profile of Patients With SMA5q Types II and III: Observational Study https://ClinicalTrials.gov/show/NCT04404764 Recruiting Hospital Israelita Albert Einstein 2020-12-31
NCT00466349 International SMA Patient Registry https://ClinicalTrials.gov/show/NCT00466349 Completed Indiana University 2018-01-31